The park is bisected by the Victoria Nile from east to west for a distance of about 115 kilometres (71 mi). The park is the location of the famous Murchison Falls, where the waters of the majestic Nile River squeeze through a narrow gorge, only 7 metres (23 ft) wide, before plunging 43 metres (141 ft) below.

It is named for the Murchison Falls waterfall, the centerpiece of the park and the final event in an 80km stretch of rapids. The mighty cascade drains the last of the river’s energy, transforming it into a broad, placid stream that flows quietly across the rift valley floor into Lake Albert. This stretch of river provides one of Uganda’s most remarkable wildlife spectacles. Regular visitors to the riverbanks include elephants, giraffes and buffaloes; while hippos, Nile crocodiles and aquatic birds are permanent residents.